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We treated 20 patients with writer's cramp in a double-blind placebo- controlled study.Each patient received two treatments in tandem,one with botulinum-A toxin(BTX-A)injections and another with normal saline, separated by 3 months.Treatment order was randomized and unknown to the patient and physician.patients were assessed before each treatment and 2 and 6 weeks after each treatment by objective measurements of pen control. Twelve patients had improvement in pen control after treatment with BTX-A, but only four had significant improvement in writing.BTX-A injections are effective in relieving symptoms in selected cases of writer's cramp, particularly in those with significant wrist-joint deviation. |
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